Filaggrin haploinsufficiency is highly penetrant and is associated with increased severity of eczema: further delineation of the skin phenotype in a prospective epidemiological study of 792 school children

BACKGROUND: Null mutations within the filaggrin gene (FLG) cause ichthyosis vulgaris and are associated with atopic eczema. However, the dermatological features of filaggrin haploinsufficiency have not been clearly defined. OBJECTIVES: This study investigated the genotype–phenotype association betwe...

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Detalhes bibliográficos
Main Authors: Brown, SJ, Relton, CL, Liao, H, Zhao, Y, Sandilands, A, McLean, WHI, Cordell, HJ, Reynolds, NJ
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2883069/
https://ncbi.nlm.nih.gov/pubmed/19681860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2133.2009.09339.x
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