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Efficient and improved synthesis of Telmisartan

An efficient synthesis of the angiotensin II receptor antagonist Telmisartan (1) is presented involving a cross coupling of 4-formylphenylboronic acid 10 with 2-(2-bromophenyl)-4,4-dimethyl-2-oxazoline (11) as the key step (90% yield). The benzimidazole moiety 15 was constructed regioselectively via...

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Detaylı Bibliyografya
Asıl Yazarlar: Kumar, A Sanjeev, Ghosh, Samir, Mehta, G N
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Beilstein-Institut 2010
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2874342/
https://ncbi.nlm.nih.gov/pubmed/20502601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.6.25
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