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4-1BB ligand as an effective multifunctional immunomodulator and antigen delivery vehicle for the development of therapeutic cancer vaccines

Therapeutic subunit vaccines based on tumor-associated antigens (TAAs) represent an attractive approach for the treatment of cancer. However, poor immunogenicity of TAAs requires potent adjuvants for therapeutic efficacy. We recently proposed the TNF family costimulatory ligands as potential adjuvan...

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Bibliografiske detaljer
Main Authors: Sharma, Rajesh K., Schabowsky, Rich-Henry, Srivastava, Abhishek K., Elpek, Kutlu G., Madireddi, Shravan, Zhao, Hong, Zhong, Zhenping, Miller, Robert W., MacLeod, Kathryn J., Yolcu, Esma S., Shirwan, Haval
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2872136/
https://ncbi.nlm.nih.gov/pubmed/20406989
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-4480
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