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Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration
Fluorescent bisretinoids, such as A2E and all-trans-retinal dimer, form as a by-product of vitamin A cycling in retina and accumulate in retinal pigment epithelial (RPE) cells as lipofuscin pigments. These pigments are implicated in pathological mechanisms involved in several vision-threatening dise...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
2010
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2867734/ https://ncbi.nlm.nih.gov/pubmed/20368460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0913112107 |
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