A Phase I Trial of a Human Papillomavirus (HPV) DNA Vaccine for HPV16+ Cervical Intraepithelial Neoplasia 2/3

PURPOSE: To evaluate the safety and immunogenicity of a therapeutic HPV16 DNA vaccine administered to women with HPV16+CIN2/3. EXPERIMENTAL DESIGN: This phase I trial incorporated the standard ‘3+3” dose escalation design with an additional 6 patients allocated to the maximally tolerated dose (MTD)....

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Hlavní autoři: Trimble, Cornelia L., Peng, Shiwen, Kos, Ferdynand, Gravitt, Patti, Viscidi, Raphael, Sugar, Elizabeth, Pardoll, Drew, Wu, TC
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865676/
https://ncbi.nlm.nih.gov/pubmed/19118066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-1725
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