Host-Detrimental Role of Esx-1-Mediated Inflammasome Activation in Mycobacterial Infection

The Esx-1 (type VII) secretion system is a major virulence determinant of pathogenic mycobacteria, including Mycobacterium marinum. However, the molecular events and host-pathogen interactions underlying Esx-1-mediated virulence in vivo remain unclear. Here we address this problem in a non-lethal mo...

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Detalhes bibliográficos
Main Authors: Carlsson, Fredric, Kim, Janice, Dumitru, Calin, Barck, Kai H., Carano, Richard A. D., Sun, Mei, Diehl, Lauri, Brown, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2865529/
https://ncbi.nlm.nih.gov/pubmed/20463815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000895
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