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Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo
We have investigated the role of Vav2, a reported Rac1/Cdc42 GEF, on the development of Xenopus spinal neurons in vitro and in vivo. Both gain and loss of Vav2 function inhibited the rate neurite extension on laminin (LN), while only GFP-Vav2 over-expression enhanced process formation and branching....
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2010
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2862809/ https://ncbi.nlm.nih.gov/pubmed/20298788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2010.03.001 |
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