Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF(δ/δ )mouse model of amyotrophic lateral sclerosis

BACKGROUND: Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen that stimulates vasculogenesis. It has also been shown to act as a neurotrophic factor in vitro and in vivo. Deletion of the hypoxia response element of the promoter region of the gene encoding VEGF in mice causes a...

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Main Authors: Brockington, Alice, Heath, Paul R, Holden, Hazel, Kasher, Paul, Bender, Florian LP, Claes, Filip, Lambrechts, Diether, Sendtner, Michael, Carmeliet, Peter, Shaw, Pamela J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861063/
https://ncbi.nlm.nih.gov/pubmed/20346106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-11-203
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