Spironolactone and hydrochlorothiazide exert antioxidant effects and reduce vascular matrix metalloproteinase-2 activity and expression in a model of renovascular hypertension

BACKGROUND AND PURPOSE: Increased oxidative stress and up-regulation of matrix metalloproteinases (MMPs) may cause structural and functional vascular changes in renovascular hypertension. We examined whether treatment with spironolactone (SPRL), hydrochlorothiazide (HCTZ) or both drugs together modi...

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Главные авторы: Ceron, CS, Castro, MM, Rizzi, E, Montenegro, MF, Fontana, V, Salgado, MCO, Gerlach, RF, Tanus-Santos, JE
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Publishing Ltd 2010
Предметы:
Research Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860208/
https://ncbi.nlm.nih.gov/pubmed/20331602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00678.x
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