Differential stability of 2′F-ANA•RNA and ANA•RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility

Hybrids of RNA with arabinonucleic acids 2′F-ANA and ANA have very similar structures but strikingly different thermal stabilities. We now present a thorough study combining NMR and other biophysical methods together with state-of-the-art theoretical calculations on a fully modified 10-mer hybrid du...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Watts, Jonathan K., Martín-Pintado, Nerea, Gómez-Pinto, Irene, Schwartzentruber, Jeremy, Portella, Guillem, Orozco, Modesto, González, Carlos, Damha, Masad J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Oxford University Press 2010
Pynciau:
Structural Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853132/
https://ncbi.nlm.nih.gov/pubmed/20071751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1225
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