Calcium-dependent Conformational Flexibility of a CUB Domain Controls Activation of the Complement Serine Protease C1r

C1, the first component of the complement system, is a Ca(2+)-dependent heteropentamer complex of C1q and two modular serine proteases, C1r and C1s. Current functional models assume significant flexibility of the subcomponents. Noncatalytic modules in C1r have been proposed to provide the flexibilit...

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Detalhes bibliográficos
Main Authors: Major, Balázs, Kardos, József, Kékesi, Katalin Adrienna, Lőrincz, Zsolt, Závodszky, Péter, Gál, Péter
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852923/
https://ncbi.nlm.nih.gov/pubmed/20178990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.098541
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