PTEN Loss Contributes to Erlotinib Resistance in EGFR-Mutant Lung Cancer by Activation of Akt and EGFR

Clinical resistance to epidermal growth factor receptor (EGFR) inhibition in lung cancer has been linked to the emergence of the EGFR T790M resistance mutation or amplification of MET. Additional mechanisms contributing to EGFR inhibitor resistance remain elusive. By applying combined analyses of ge...

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Main Authors: Sos, Martin L., Koker, Mirjam, Weir, Barbara A., Heynck, Stefanie, Rabinovsky, Rosalia, Zander, Thomas, Seeger, Jens M., Weiss, Jonathan, Fischer, Florian, Frommolt, Peter, Michel, Kathrin, Peifer, Martin, Mermel, Craig, Girard, Luc, Peyton, Michael, Gazdar, Adi F., Minna, John D., Garraway, Levi A., Kashkar, Hamid, Pao, William, Meyerson, Matthew, Thomas, Roman K.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849653/
https://ncbi.nlm.nih.gov/pubmed/19351834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-08-4055
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