Distinct p53, p53:LANA, and LANA Complexes in Kaposi's Sarcoma-Associated Herpesvirus Lymphomas

The role of p53 in primary effusion lymphoma (PEL) is complicated. The latency-associated nuclear antigen (LANA) of Kaposi's sarcoma-associated herpesvirus (KSHV) binds p53. Despite this interaction, we had found that p53 was functional in PEL, i.e., able to induce apoptosis in response to DNA...

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Bibliographic Details
Main Authors: Chen, Wuguo, Hilton, Isaac B., Staudt, Michelle R., Burd, Christin E., Dittmer, Dirk P.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Transformation and Oncogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849491/
https://ncbi.nlm.nih.gov/pubmed/20130056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01321-09
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