Role of IL-17A, IL-17F, and the IL-17 Receptor in Regulating Growth-Related Oncogene-α and Granulocyte Colony-Stimulating Factor in Bronchial Epithelium: Implications for Airway Inflammation in Cystic Fibrosis

IL-17R signaling is critical for pulmonary neutrophil recruitment and host defense against Gram-negative bacteria through the coordinated release of G-CSF and CXC chemokine elaboration. In this study, we show that IL-17R is localized to basal airway cells in human lung tissue, and functional IL-17R...

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Main Authors: McAllister, Florencia, Henry, Adam, Kreindler, James L., Dubin, Patricia J., Ulrich, Lauren, Steele, Chad, Finder, Jonathan D., Pilewski, Joseph M., Carreno, Beatriz M., Goldman, Samuel J., Pirhonen, Jaana, Kolls, Jay K.
Format: Artigo
Language:Inglês
Published: 2005
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2849297/
https://ncbi.nlm.nih.gov/pubmed/15972674
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