Diminishing Efficacy of Combination Therapy, Response-Heterogeneity, and Treatment Intolerance Limit the Attainability of Tight Risk Factor Control in Patients with Diabetes

OBJECTIVE: To evaluate the attainability of tight risk factor control targets for three diabetes risk factors and to assess the degree of polypharmacy required. DATA SOURCES/STUDY SETTING: National Health and Nutrition Examination Survey-III. STUDY DESIGN: We simulated a strategy of “treating to tar...

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Bibliographic Details
Main Authors: Timbie, Justin W, Hayward, Rodney A, Vijan, Sandeep
Format: Artigo
Language:Inglês
Published: Blackwell Science Inc 2010
Subjects:
Major Illness and Chronic Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838154/
https://ncbi.nlm.nih.gov/pubmed/20070387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1475-6773.2009.01075.x
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