Inhibition of gut-derived serotonin synthesis: a potential bone anabolic treatment

Osteoporosis is a low bone mass disease most often caused by an increase in bone resorption not compensated by a similar hike in bone formation1. Since gut–derived serotonin (GDS) inhibits bone formation2, we asked whether hampering its biosynthesis could treat osteoporosis through an anabolic mecha...

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Autors principals: Yadav, Vijay K., Balaji, Santhanam, Suresh, P.S., Liu, X. Sherry, Lu, Xin, Li, Zhishan, Guo, X. Edward, Mann, J. John, Balapure, Anil K., Gershon, Michael D., Medhamurthy, R., Vidal, Marc, Karsenty, Gerard, Ducy, Patricia
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836724/
https://ncbi.nlm.nih.gov/pubmed/20139991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2098
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