Inhibition of gut-derived serotonin synthesis: a potential bone anabolic treatment

Osteoporosis is a low bone mass disease most often caused by an increase in bone resorption not compensated by a similar hike in bone formation1. Since gut–derived serotonin (GDS) inhibits bone formation2, we asked whether hampering its biosynthesis could treat osteoporosis through an anabolic mecha...

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Autori principali: Yadav, Vijay K., Balaji, Santhanam, Suresh, P.S., Liu, X. Sherry, Lu, Xin, Li, Zhishan, Guo, X. Edward, Mann, J. John, Balapure, Anil K., Gershon, Michael D., Medhamurthy, R., Vidal, Marc, Karsenty, Gerard, Ducy, Patricia
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2836724/
https://ncbi.nlm.nih.gov/pubmed/20139991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.2098
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