Immune Response of Mice Transgenic for Human Histocompatibility Leukocyte Antigen-DR to Human Thyrotropin Receptor-Extracellular Domain

BACKGROUND: Hyperthyroidism of Graves' disease is caused by auto-antibodies to human thyrotropin receptor (hTSH-R). To elucidate important T-cell epitopes in TSH-R, we studied three models of immunity to TSH-R in mice. METHODS: Mice transgenic for histocompatibility leukocyte antigen DR3 or DR2...

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Bibliografiska uppgifter
Huvudupphovsmän: Inaba, Hidefumi, Pan, Deshun, Shin, Young-Ha, Martin, William, Buchman, George, De Groot, Leslie J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Mary Ann Liebert, Inc. 2009
Ämnen:
Original Studies, Reviews, and Scholarly Dialog
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2833177/
https://ncbi.nlm.nih.gov/pubmed/19725778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2008.0349
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