Directed Evolution of a Novel Adeno-associated Virus (AAV) Vector That Crosses the Seizure-compromised Blood–Brain Barrier (BBB)

DNA shuffling and directed evolution were employed to develop a novel adeno-associated virus (AAV) vector capable of crossing the seizure-compromised blood–brain barrier (BBB) and transducing cells in the brain. Capsid DNA from AAV serotypes 1–6, 8, and 9 were shuffled and recombined to create a lib...

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Main Authors: Gray, Steven J, Blake, Bonita L, Criswell, Hugh E, Nicolson, Sarah C, Samulski, R Jude, McCown, Thomas J
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2009
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2831133/
https://ncbi.nlm.nih.gov/pubmed/20040913
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2009.292
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