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Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C19*17

AIMS: Cytochrome P450 2C19 metabolizes many important drugs. In 2006, a variant allele (CYP2C19*17) associated with increased activity was discovered, but its likely clinical significance is controversial. Investigators disagree about the phenotype to be assigned to the two CYP2C19*17 genotypes. The...

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Hlavní autoři: Li-Wan-Po, Alain, Girard, Thierry, Farndon, Peter, Cooley, Candy, Lithgow, James
Médium: Artigo
Jazyk:Inglês
Vydáno: Blackwell Science Inc 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829691/
https://ncbi.nlm.nih.gov/pubmed/20233192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03578.x
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