Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation

Group I metabotropic glutamate receptors (mGluRs) are coupled via Gα(q/11 )to the activation of phospholipase Cβ, which hydrolyzes membrane phospholipids to form inositol 1,4,5 trisphosphate and diacylglycerol. This results in the release of Ca(2+ )from intracellular stores and the activation of pro...

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Autori principali: Nicodemo, Alexander A, Pampillo, Macarena, Ferreira, Lucimar T, Dale, Lianne B, Cregan, Tamara, Ribeiro, Fabiola M, Ferguson, Stephen SG
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2010
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2829546/
https://ncbi.nlm.nih.gov/pubmed/20180987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-3-4
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