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Effects of nicotine on cytochrome P450 2A6 and 2E1 activities

AIMS: Smoking slows the metabolism of nicotine and accelerates the metabolism of chlorzoxazone, which are probe reactions for cytochrome P450 2A6 (CYP2A6) and CYP2E1 activities, respectively. We aimed to determine the role of nicotine in these metabolic effects of cigarette smoking. METHODS: The stu...

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Main Authors: Hukkanen, Janne, Jacob, Peyton, Peng, Margaret, Dempsey, Delia, Benowitz, Neal L
格式: Artigo
語言:Inglês
出版: Blackwell Science Inc 2010
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824476/
https://ncbi.nlm.nih.gov/pubmed/20233178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03568.x
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