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Effects of nicotine on cytochrome P450 2A6 and 2E1 activities

AIMS: Smoking slows the metabolism of nicotine and accelerates the metabolism of chlorzoxazone, which are probe reactions for cytochrome P450 2A6 (CYP2A6) and CYP2E1 activities, respectively. We aimed to determine the role of nicotine in these metabolic effects of cigarette smoking. METHODS: The stu...

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Détails bibliographiques
Auteurs principaux: Hukkanen, Janne, Jacob, Peyton, Peng, Margaret, Dempsey, Delia, Benowitz, Neal L
Format: Artigo
Langue:Inglês
Publié: Blackwell Science Inc 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2824476/
https://ncbi.nlm.nih.gov/pubmed/20233178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2125.2009.03568.x
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