Unusual lipid structures selectively reduce the toxicity of amphotericin B.

Ribbon-like structures result when amphotericin B interacts with lipid in an aqueous environment. At high ratios of amphotericin to lipid these structures, which are lipid-stabilized amphotericin aggregates, become prevalent resulting in a dramatic attenuation of amphotericin-mediated mammalian cell...

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Detalhes bibliográficos
Main Authors: Janoff, A S, Boni, L T, Popescu, M C, Minchey, S R, Cullis, P R, Madden, T D, Taraschi, T, Gruner, S M, Shyamsunder, E, Tate, M W
Formato: Artigo
Idioma:Inglês
Publicado em: 1988
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC281917/
https://ncbi.nlm.nih.gov/pubmed/3413081
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