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Molecular footprints of a germinal center derivation of human IgM(+)(IgD(+))CD27(+) B cells and the dynamics of memory B cell generation

The origin of IgM(+)CD27(+) B lymphocytes with mutated IgV genes, which account for ∼20% of human peripheral blood (PB) B cells, is controversially discussed. A generation in a primary diversification pathway, in T cell–independent immune responses, or in T cell–dependent germinal center (GC) reacti...

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Bibliografiske detaljer
Main Authors: Seifert, Marc, Küppers, Ralf
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806629/
https://ncbi.nlm.nih.gov/pubmed/19917772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20091087
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