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Interplay between Akt and p38 MAPK pathways in the regulation of renal tubular cell apoptosis associated with diabetic nephropathy

Hyperglycemia induces p38 MAPK-mediated renal proximal tubular cell (RPTC) apoptosis. The current study hypothesized that alteration of the Akt signaling pathway by hyperglycemia may contribute to p38 MAPK activation and development of diabetic nephropathy. Immunoblot analysis demonstrated a hypergl...

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Autori principali: Rane, Madhavi J., Song, Ye, Jin, Shunying, Barati, Michelle T., Wu, Rui, Kausar, Hina, Tan, Yi, Wang, Yuehui, Zhou, Guihua, Klein, Jon B., Li, Xiaokun, Cai, Lu
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2806120/
https://ncbi.nlm.nih.gov/pubmed/19726550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00032.2009
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