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Activation of FcγR1 on monocytes triggers differentiation into immature dendritic cells that induce autoreactive T cell responses

The formation of immune complexes results in activation of the innate immune system and subsequent induction of host inflammatory responses. In particular, the binding of IgG immune complexes to Fcγ receptors (FcγR) on monocytes triggers potent inflammatory responses leading to tissue injury in dise...

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Bibliographic Details
Main Authors: Tanaka, Motoyuki, Krutzik, Stephan R., Sieling, Peter A., Lee, Delphine, Rea, Thomas H., Modlin, Robert L.
Format: Artigo
Language:Inglês
Published: 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2790276/
https://ncbi.nlm.nih.gov/pubmed/19635920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0801683
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