Depletion of Vitamin E Increases Amyloid β Accumulation by Decreasing Its Clearances from Brain and Blood in a Mouse Model of Alzheimer Disease

Increased oxidative damage is a prominent and early feature in Alzheimer disease. We previously crossed Alzheimer disease transgenic (APPsw) model mice with α-tocopherol transfer protein knock-out (Ttpa(−/−)) mice in which lipid peroxidation in the brain was significantly increased. The resulting do...

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Detalhes bibliográficos
Main Authors: Nishida, Yoichiro, Ito, Shingo, Ohtsuki, Sumio, Yamamoto, Naoki, Takahashi, Tsubura, Iwata, Nobuhisa, Jishage, Kou-ichi, Yamada, Hiromi, Sasaguri, Hiroki, Yokota, Shigefumi, Piao, Wenying, Tomimitsu, Hiroyuki, Saido, Takaomi C., Yanagisawa, Katsuhiko, Terasaki, Tetsuya, Mizusawa, Hidehiro, Yokota, Takanori
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Lipids and Lipoproteins: Metabolism, Regulation, and Signaling
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2785184/
https://ncbi.nlm.nih.gov/pubmed/19679659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.054056
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