Interaction of Macrolide Antibiotics with Intestinally Expressed Human and Rat Organic Anion-Transporting Polypeptides

The macrolide antibiotics azithromycin and clarithromycin are large molecular weight compounds that exhibit moderate to excellent oral bioavailability in preclinical species and humans. Previous concomitant dosing studies in rats using rifamycin SV, a general organic anion-transporting polypeptide (...

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Main Authors: Lan, Tian, Rao, Anuradha, Haywood, Jamie, Davis, Charles B., Han, Chao, Garver, Eric, Dawson, Paul A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: The American Society for Pharmacology and Experimental Therapeutics 2009
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Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2784704/
https://ncbi.nlm.nih.gov/pubmed/19741038
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.109.028522
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