Stereochemical Configuration of 4-Hydroxy-2-nonenal-Cysteine Adducts and Their Stereoselective Formation in a Redox-regulated Protein

4-Hydroxy-2-nonenal (HNE), a major racemic product of lipid peroxidation, preferentially reacts with cysteine residues to form a stable HNE-cysteine Michael addition adduct possessing three chiral centers. Here, to gain more insight into sulfhydryl modification by HNE, we characterized the stereoche...

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Bibliographic Details
Main Authors: Wakita, Chika, Maeshima, Takuya, Yamazaki, Atsushi, Shibata, Takahiro, Ito, Sohei, Akagawa, Mitsugu, Ojika, Makoto, Yodoi, Junji, Uchida, Koji
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Protein Synthesis, Post-Translational Modification, and Degradation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2781427/
https://ncbi.nlm.nih.gov/pubmed/19692331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.019927
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