Abnormal TDP-43 immunoreactivity in AD modifies clinicopathological and radiological phenotype

BACKGROUND: TAR DNA-binding protein 43 (TDP-43) is one of the major disease proteins in frontotemporal lobar degeneration with ubiquitin immunoreactivity. Approximately 1/4 of subjects with pathologically confirmed Alzheimer's disease (AD) have abnormal TDP-43 (abTDP-43) immunoreactivity. The a...

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Hlavní autoři: Josephs, Keith A., Whitwell, Jennifer L., Knopman, David S., Hu, William T., Stroh, D. Alex, Baker, Matthew, Rademakers, Rosa, Boeve, Bradley F., Parisi, Joseph E., Smith, Glenn E., Ivnik, Robert J., Petersen, Ronald C., Jack, Clifford R., Dickson, Dennis W.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779031/
https://ncbi.nlm.nih.gov/pubmed/18401022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/01.wnl.0000304041.09418.b1
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