Abnormal TDP-43 immunoreactivity in AD modifies clinicopathological and radiological phenotype

BACKGROUND: TAR DNA-binding protein 43 (TDP-43) is one of the major disease proteins in frontotemporal lobar degeneration with ubiquitin immunoreactivity. Approximately 1/4 of subjects with pathologically confirmed Alzheimer's disease (AD) have abnormal TDP-43 (abTDP-43) immunoreactivity. The a...

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Detalhes bibliográficos
Main Authors: Josephs, Keith A., Whitwell, Jennifer L., Knopman, David S., Hu, William T., Stroh, D. Alex, Baker, Matthew, Rademakers, Rosa, Boeve, Bradley F., Parisi, Joseph E., Smith, Glenn E., Ivnik, Robert J., Petersen, Ronald C., Jack, Clifford R., Dickson, Dennis W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2779031/
https://ncbi.nlm.nih.gov/pubmed/18401022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1212/01.wnl.0000304041.09418.b1
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