HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis

BACKGROUND: In the Step Study, the MRKAd5 HIV-1 gag/pol/nef vaccine did not lower post-infection plasma viremia, and HIV-1 incidence was higher in vaccine-treated than placebo-treated males with pre-existing adenovirus serotype 5 (Ad5) immunity. We evaluated vaccine-induced immunity and its potentia...

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Main Authors: McElrath, M. Juliana, De Rosa, Stephen C., Moodie, Zoe, Dubey, Sheri, Kierstead, Lisa, Janes, Holly, Defawe, Olivier D., Carter, Donald K., Hural, John, Akondy, Rama, Buchbinder, Susan P., Robertson, Michael N., Mehrotra, Devan V., Self, Steven G., Corey, Lawrence, Shiver, John W., Casimiro, Danilo R.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774110/
https://ncbi.nlm.nih.gov/pubmed/19012957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(08)61592-5
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