HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis

BACKGROUND: In the Step Study, the MRKAd5 HIV-1 gag/pol/nef vaccine did not lower post-infection plasma viremia, and HIV-1 incidence was higher in vaccine-treated than placebo-treated males with pre-existing adenovirus serotype 5 (Ad5) immunity. We evaluated vaccine-induced immunity and its potentia...

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Hauptverfasser: McElrath, M. Juliana, De Rosa, Stephen C., Moodie, Zoe, Dubey, Sheri, Kierstead, Lisa, Janes, Holly, Defawe, Olivier D., Carter, Donald K., Hural, John, Akondy, Rama, Buchbinder, Susan P., Robertson, Michael N., Mehrotra, Devan V., Self, Steven G., Corey, Lawrence, Shiver, John W., Casimiro, Danilo R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2008
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2774110/
https://ncbi.nlm.nih.gov/pubmed/19012957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S0140-6736(08)61592-5
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