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Selective Use of ADAM10 and ADAM17 in Activation of Notch1 Signaling
Notch signaling requires a series of proteolytic cleavage events to release the Notch intracellular domain (NICD) that functions directly in signal transduction. The Notch receptor is locked down in a protease-resistant state by a negative regulatory region (NRR) that protects an ADAM (a disintegrin...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology (ASM)
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2772745/ https://ncbi.nlm.nih.gov/pubmed/19704010 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00406-09 |
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