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Unique quadruplex structure and interaction of an RNA aptamer against bovine prion protein
RNA aptamers against bovine prion protein (bPrP) were obtained, most of the obtained aptamers being found to contain the r(GGAGGAGGAGGA) (R12) sequence. Then, it was revealed that R12 binds to both bPrP and its β-isoform with high affinity. Here, we present the structure of R12. This is the first re...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2764455/ https://ncbi.nlm.nih.gov/pubmed/19666719 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp647 |
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