Intratracheal synthetic CpG oligodeoxynucleotide causes acute lung injury with systemic inflammatory response

Bacterial genome is characterized by frequent unmethylated cytosine-phosphate-guanine (CpG) motifs. Deleterious effects can occur when synthetic oligodeoxynucleotides (ODN) with unmethylated CpG dinucleotides (CpG-ODN) are administered in a systemic fashion. We aimed to evaluate the effect of intrat...

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Bibliographic Details
Main Authors: Tasaka, Sadatomo, Kamata, Hirofumi, Miyamoto, Keisuke, Nakano, Yasushi, Shinoda, Hiromi, Kimizuka, Yoshifumi, Fujiwara, Hiroshi, Hasegawa, Naoki, Fujishima, Seitaro, Miyasho, Taku, Ishizaka, Akitoshi
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2761862/
https://ncbi.nlm.nih.gov/pubmed/19772669
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-10-84
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