Effects of Cardiac Myosin Isoform Variation on Myofilament Function and Crossbridge Kinetics in Transgenic Rabbits

BACKGROUND: The left ventricles (LV) of both rabbits and humans express predominantly β-myosin heavy chain (MHC). Transgenic (TG) rabbits expressing 40% α-MHC are protected against tachycardia-induced cardiomyopathy (TIC), but the normal amount of α-MHC expressed in humans is only 5-7% and its funct...

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Bibliografiske detaljer
Main Authors: Suzuki, Takeki, Palmer, Bradley M., James, Jeanne, Wang, Yuan, Chen, Zengyi, VanBuren, Peter, Maughan, David W., Robbins, Jeffrey, LeWinter, Martin M.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2760018/
https://ncbi.nlm.nih.gov/pubmed/19808357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.108.802298
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