Using distinct molecular signatures of human monocytes and dendritic cells to predict adjuvant activity and pyrogenicity of TLR agonists

We present a systematic study that defines molecular profiles of adjuvanticity and pyrogenicity induced by agonists of human Toll-like receptor molecules in vitro. Using P(3)CSK(4), Lipid A and Poly I:C as model adjuvants we show that all three molecules enhance the expansion of IFNγ(+)/CD4(+) T cel...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Kamgang, Richard Kenmoe, Ramos, Inês, Rodrigues Duarte, Lurdes, Ghielmetti, Mascia, Freudenberg, Marina, Dahinden, Clemens, Padovan, Elisabetta
Format: Artigo
Langue:Inglês
Publié: Springer-Verlag 2008
Sujets:
Original Investigation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757590/
https://ncbi.nlm.nih.gov/pubmed/18283493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00430-008-0081-6
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