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Flexible Filaments for in vivo Imaging and Delivery: Persistent Circulation of Filomicelles Opens the Dosage Window for Sustained Tumor Shrinkage

Shape effects of synthetic carriers are largely unexplored in vivo, although recent findings suggest that flexible filaments can persist in the circulation even if microns in length. Here, to better assess biodistribution, a near infrared fluorophore (NIRF) was incorporated into such block copolymer...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Christian, David A., Cai, Shenshen, Garbuzenko, Olga B., Harada, Takamasa, Zajac, Allison L., Minko, Tamara, Discher, Dennis E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2757530/
https://ncbi.nlm.nih.gov/pubmed/19249859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp900022m
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