GLI3 Repressor Controls Nephron Number via Regulation of Wnt11 and Ret in Ureteric Tip Cells

Truncating GLI3 mutations in Pallister-Hall Syndrome with renal malformation suggests a requirement for Hedgehog signaling during renal development. HH-dependent signaling increases levels of GLI transcriptional activators and decreases processing of GLI3 to a shorter transcriptional repressor. Prev...

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Bibliografiske detaljer
Main Authors: Cain, Jason E., Islam, Epshita, Haxho, Fiona, Chen, Lin, Bridgewater, Darren, Nieuwenhuis, Erica, Hui, Chi-Chung, Rosenblum, Norman D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754339/
https://ncbi.nlm.nih.gov/pubmed/19809516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007313
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