Splenectomy Normalizes Hematocrit in Murine Polycythemia Vera

Splenic enlargement (splenomegaly) develops in numerous disease states, although a specific pathogenic role for the spleen has rarely been described. In polycythemia vera (PV), an activating mutation in Janus kinase 2 (JAK2(V617)) induces splenomegaly and an increase in hematocrit. Splenectomy is sp...

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Bibliographic Details
Main Authors: Mo, Jan-Rung, Mathur, Anjili, Angagaw, Minilik, Zhao, Shuxia, Wang, Yuxun, Gargano, Diana, DiBacco, Alessandra, Bachman, Eric S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749451/
https://ncbi.nlm.nih.gov/pubmed/19789710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007286
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