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Splenectomy Normalizes Hematocrit in Murine Polycythemia Vera
Splenic enlargement (splenomegaly) develops in numerous disease states, although a specific pathogenic role for the spleen has rarely been described. In polycythemia vera (PV), an activating mutation in Janus kinase 2 (JAK2(V617)) induces splenomegaly and an increase in hematocrit. Splenectomy is sp...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2749451/ https://ncbi.nlm.nih.gov/pubmed/19789710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007286 |
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