Direct Activation of Protein Kinases by Unanchored Polyubiquitin Chains

TRAF6 is a ubiquitin ligase essential for the activation of NF-κB and MAP kinases in multiple signaling pathways including those emanating from the interleukin-1 and Toll-like receptors (IL-1R/TLR)1-3. TRAF6 functions together with a ubiquitin-conjugating enzyme complex consisting of Ubc13 and Uev1A...

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Autori principali: Xia, Zong-Ping, Sun, Lijun, Chen, Xiang, Pineda, Gabriel, Jiang, Xiaomo, Adhikari, Anirban, Zeng, Wenwen, Chen, Zhijian J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747300/
https://ncbi.nlm.nih.gov/pubmed/19675569
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08247
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