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Direct Activation of Protein Kinases by Unanchored Polyubiquitin Chains
TRAF6 is a ubiquitin ligase essential for the activation of NF-κB and MAP kinases in multiple signaling pathways including those emanating from the interleukin-1 and Toll-like receptors (IL-1R/TLR)1-3. TRAF6 functions together with a ubiquitin-conjugating enzyme complex consisting of Ubc13 and Uev1A...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2747300/ https://ncbi.nlm.nih.gov/pubmed/19675569 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08247 |
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