Impairment of insulin-stimulated Akt/GLUT4 signaling is associated with cardiac contractile dysfunction and aggravates I/R injury in STZ-diabetic Rats

In this study, we established systemic in-vivo evidence from molecular to organism level to explain how diabetes can aggravate myocardial ischemia-reperfusion (I/R) injury and revealed the role of insulin signaling (with specific focus on Akt/GLUT4 signaling molecules). The myocardial I/R injury was...

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Autores principales: Huang, Jiung-Pang, Huang, Shiang-Suo, Deng, Jen-Ying, Hung, Li-Man
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2009
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2740847/
https://ncbi.nlm.nih.gov/pubmed/19706162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-16-77
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