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Profound Antiviral Effect of Oral Administration of MIV-210 on Chronic Hepadnaviral Infection in a Woodchuck Model of Hepatitis B

MIV-210 is a prodrug of 3′-fluoro-2′,3′-dideoxyguanosine with high oral bioavailability in humans and potent activity against hepatitis B virus (HBV). Woodchucks infected with woodchuck hepatitis virus (WHV) represent an accurate model of HBV infection that is utilized for evaluation of the efficacy...

詳細記述

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書誌詳細
主要な著者: Michalak, Tomasz I., Zhang, Hong, Churchill, Norma D., Larsson, Torbjörn, Johansson, Nils-Gunnar, Öberg, Bo
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737870/
https://ncbi.nlm.nih.gov/pubmed/19564357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00263-09
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