Common variants in the NLRP3 region contribute to Crohn's disease susceptibility

We used a candidate gene approach to identify a set of SNPs, located in a predicted regulatory region on chromosome 1q44 downstream of NLRP3 (previously known as CIAS1 and NALP3), that are associated with Crohn's disease. The associations were consistently replicated in four sample sets from in...

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Auteurs principaux: Villani, Alexandra-Chloé, Lemire, Mathieu, Fortin, Geneviève, Louis, Edouard, Silverberg, Mark S, Collette, Catherine, Baba, Nobuyasu, Libioulle, Cécile, Belaiche, Jacques, Bitton, Alain, Gaudet, Daniel, Cohen, Albert, Langelier, Diane, Fortin, Paul R, Wither, Joan E, Sarfati, Marika, Rutgeerts, Paul, Rioux, John D, Vermeire, Severine, Hudson, Thomas J, Franchimont, Denis
Format: Artigo
Langue:Inglês
Publié: 2008
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728932/
https://ncbi.nlm.nih.gov/pubmed/19098911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng285
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