Sterol Regulatory Element Binding Protein 1a Regulates Hepatic Fatty Acid Partitioning by Activating Acetyl Coenzyme A Carboxylase 2

We generated a line of mice in which sterol regulatory element binding protein 1a (SREBP-1a) was specifically inactivated by insertional mutagenesis. Homozygous mutant mice were completely viable despite expressing SREBP-1a mRNA below 5% of normal, and there were minimal effects on expression of eit...

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Main Authors: Im, Seung-Soon, Hammond, Linda E., Yousef, Leyla, Nugas-Selby, Cherryl, Shin, Dong-Ju, Seo, Young-Kyo, Fong, Loren G., Young, Stephen G., Osborne, Timothy F.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725716/
https://ncbi.nlm.nih.gov/pubmed/19564420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00553-09
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