Evaluation of Lapatinib and Topotecan Combination Therapy: Tissue Culture, Murine Xenograft, and Phase I Clinical Trial Data

PURPOSE: Topotecan resistance can result from drug efflux by P-glycoprotein (Pgp) and breast cancer resistance protein (BCRP) as well as survival signals initiated by epidermal growth factor receptor family members. The present studies were done to determine the effect of combining topotecan and the...

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Main Authors: Molina, Julian R., Kaufmann, Scott H., Reid, Joel M., Rubin, Stephen D., Gálvez-Peralta, Marina, Friedman, Robert, Flatten, Karen S., Koch, Kevin M., Gilmer, Tona M., Mullin, Robert J., Jewell, Roxanne C., Felten, Sara J., Mandrekar, Sumithra, Adjei, Alex A., Erlichman, Charles
Format: Artigo
Sprog:Inglês
Udgivet: 2008
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2725396/
https://ncbi.nlm.nih.gov/pubmed/19047120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-0415
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